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KMID : 0350519960490041385
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Journal of Catholic Medical College
1996 Volume.49 No. 4 p.1385 ~ p.1398
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Numerical Chromosome Aberrations and Loss of Heterozygosity in Bladder Cancer Using Non-
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Abstract
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By the development of cytogenetics and molecular genetics, it is generally accepted that numerical aberration and deletion of specific chromosome is closely related with carcinogenetic process. However, the conventional cytogenetics have
limitations in
chromosome study due to metaphase analysis and limited type of probe. Recently in situ hybridization of interphase cells and loss of heterozygosity using microsatellite markers have been introduced for the molecular cytogenetic study in
paraffin-embedded solid tumor. In order to investigate the centromeric copy number, loss of heterozygosity and instability in their relations to tumor grade or stage, the authors performed interphase cytogenetics by non-fluorescent in situ
hybridization
on chromosome 7,9 and 17 and microsatellite analysis on long arm of chromosome 9 in 21 cases of bladder cancer.
@ES The results were as follows:
@EN 1. Nineteen out of twenty one patients revealed numerical aberration at one or more chromosome. The changes of chromosome number were most frequently found in chromosome 7 (15 cases) followed by chromosome 9 (13 cases) and 17 (11 cases).
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